Table 7.
NACT cycle-wise diagnostic accuracy of CEUS quantitative parameters in predicting response to NACT
| Variable | Instance | Sensitivity | Specificity | PPV | NPV | Diagnostic Accuracy | p-value |
|---|---|---|---|---|---|---|---|
| PE (E1%) | Post first cycle | 88.2% | 38.5% | 65.2% | 71.4% | 66.7% | 0.152 |
| Post second cycle | 52.9% | 76.9% | 75.0% | 55.6% | 63.3% | 0.414 | |
| Post third cycle | 47.1% | 100.0% | 100.0% | 59.1% | 70.0% | 0.106 | |
| TTP (E1s) | Post first cycle | 41.2% | 76.9% | 70.0% | 50.0% | 56.7% | 0.950 |
| Post second cycle | 58.8% | 76.9% | 76.9% | 58.8% | 66.7% | 0.124 | |
| Post third cycle | 84.2% | 94.5% | 93.7% | 81.0% | 87.2% | 0.003 | |
| AUC (E3%s) | Post first cycle | 82.4% | 38.5% | 63.6% | 62.5% | 63.3% | 0.720 |
| Post second cycle | 82.4% | 38.5% | 63.6% | 62.5% | 63.3% | 0.933 | |
| Post third cycle | 64.7% | 69.2% | 73.3% | 60.0% | 66.7% | 0.212 | |
| MTT (E1s) | Post first cycle | 41.2% | 84.6% | 77.8% | 52.4% | 60.0% | 0.513 |
| Post second cycle | 70.6% | 84.6% | 85.7% | 68.8% | 76.7% | 0.004 | |
| Post third cycle | 82.4% | 92.3% | 93.3% | 80.0% | 86.7% | 0.006 |
AUC, area under the curve; CEUS, contrast-enhanced ultrasound; NACT, neoadjuvant chemotherapy; NPV, negative predictive value; PE, peak enhancement; PPV, positive predictive value; TTP, time-to-peak.