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. 2021 Sep 28;12:742881. doi: 10.3389/fimmu.2021.742881

Figure 3.

Figure 3

The frequency of each candidate allotype and amino acid residue encoded in the Major Histocompatibility Complex (MHC) associated with susceptibility to SARS-CoV-2 symptomatic infection or with asymptomatic and seronegative after exposure. COVID-19[+]: Patients with symptomatic COVID-19. COVID-19[-]: Individuals sharing the same bed with symptomatic patients (exposed individuals) and are asymptomatic and seronegative. P-value (1): Logistic regression comparing all COVID-19[+] and all COVID-19[-] individuals, controlling for sex, age, and genetic ancestry; P-value (2): Logistic regression comparing COVID-19[+] and COVID-19[-] individuals, controlling for age, and genetic ancestry; P-value (3): Fisher exact test, comparing COVID-19[+] or COVID-19[-] individuals with a population sample paired by gender and genetic ancestry. In green, P-values < 0.005; In yellow, P-value between 0.005 and 0.05. Notes: (A) DOB*01:02 is the only HLA-DOB allotype carrying residue 18Q; (B) MICB*004, *024, *028 carry residue 75N (residue 75 in the full-length protein); (C) This residue is common to many HLA-A alleles, including A*23:01, A*25:01, A*26:01, *29:02, *30:01, *30:02, *31:01, *32:01, *33:01; (D) This residue is common to many HLA-A allotypes, including A*23:01, *29:02, *30:01, *30:02, *31:01, *32:01, *33:01; (E) This residue occurs in DRB1*03:01, *03:02, *04:01,*04:09, *13:03. rs9269942/T captures only a fraction of the sequences encoding K at position 101 from HLA-DRB1, since the composition of other surrounding variants, including indels, can produce the codon for K.