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Overall sample size, number of events, and hazard ratios for the primary endpoint by R4 category.
| R4 Category (# of criteria) | n= | Events | HR | p-value | 95 %CI | Bootstrap 95% CI |
|---|---|---|---|---|---|---|
| 1 (0) | 58 | 8 (14%) | – | – | – | – |
| 2 (1) | 173 | 53 (31%) | 2.94 | < 0.001 | 1.67–5.19 | 1.65–5.26 |
| 3 (2–3) | 215 | 96 (45%) | 4.08 | < 0.001 | 2.41–6.93 | 2.36–7.05 |
| 4 (≥4) | 83 | 56 (67%) | 6.63 | < 0.001 | 3.76–11.70 | 3.74–11.77 |
