Table 1. Univariate and Multivariate Analysis for First Clinical Demyelinating Event.
| Variable | Patient population, No. | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age <37 y | 354 | 3.52 (1.80-6.88) | <.001 | 4.04 (2.00-8.15) | <.001 |
| Women | 354 | 1.27 (0.68-2.36) | .45 | NA | NA |
| Positive family MS history | 354 | 0.86 (0.36-1.81) | .73 | NA | NA |
| MRI motive (headache) | 354 | 0.64 (0.32-1.28) | .21 | NA | NA |
| Positive CSF IgG index >0.7l or presence of >2 unique OCBs | 354 | 1.26 (0.51-3.09) | .61 | NA | NA |
| Not >3 periventricular lesions | 349 | 1.59 (0.57-4.45) | .38 | NA | NA |
| Infratentorial lesion presence | 349 | 1.76 (0.98-3.15) | .06 | NA | NA |
| Juxtacortical lesion presence | 349 | NAa | NA | NA | NA |
| Spinal cord lesion presence | 173 | 3.82 (1.50-9.70) | .005 | 5.11 (1.99-13.13) | .001 |
| Gadolinium-enhancing lesions on index MRI | 354 | 2.11 (1.16-3.83) | .01 | 2.09 (1.33-3.87) | .02 |
| Disease modifying treatment) | 61 | 7.49 (4.24-13.24) | <.001 | 0.85 (0.26-2.81) | .79 |
Abbreviations: CSF, cerebrospinal fluid; HR, hazard ratio; MRI, magnetic resonance imaging; MS, multiple sclerosis; NA, not applicable; OCB, oligoclonal band.
a
This result was not estimable given that no clinical conversion was observed for patients with juxtacortical lesions.