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. 2021 Oct 12;375:n2321. doi: 10.1136/bmj.n2321

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Fig 2 — Treatment effect on osteoarthritis pain and dropouts due to adverse events compared with oral placebo, ordered according to treatment effect size on osteoarthritis pain. Blue: oral non-steroidal anti-inflammatory drugs; green: topical non-steroidal anti-inflammatory drugs; orange: opioids. Area between dashed lines shows treatment effect estimates below the minimum clinically important difference. See web-appendix 17 for caterpillar plot ordered according to odds ratio of dropouts due to adverse events. See table 2, table 3, and web-appendix 7 for specific estimates with 95% CrI and additional outcome. *Maximum daily recommended dose. CrI=credible interval