Skip to main content
. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2021 May 12;41:116215. doi: 10.1016/j.bmc.2021.116215

Table 2.

Allosteric Antagonist Potencies of Compounds 21-31 in the hCB1 Calcium Mobilization Assay.

graphic file with name nihms-1705294-t0024.jpg
Compound Structure pIC50a Compound Structure pIC50a
21 graphic file with name nihms-1705294-t0025.jpg 5.4 ± 0.09 27 graphic file with name nihms-1705294-t0031.jpg < 5
22 graphic file with name nihms-1705294-t0026.jpg < 5 28 graphic file with name nihms-1705294-t0032.jpg < 5
23 graphic file with name nihms-1705294-t0027.jpg < 5 29 graphic file with name nihms-1705294-t0033.jpg < 5
24 graphic file with name nihms-1705294-t0028.jpg 5.8 ± 0.03 30 graphic file with name nihms-1705294-t0034.jpg < 5
25 graphic file with name nihms-1705294-t0029.jpg 6.1 ± 0.01 31 NHCOMe 5.8 ± 0.09
26 graphic file with name nihms-1705294-t0030.jpg 6.6 ± 0.06
a

Compounds tested against EC80 (100 nM) of CP55,940. Values are the mean ± SEM of at least three independent experiments in duplicate.