Table 3.

Predictors of each quality of life trajectory (SF-36) across baseline, 3–5 year and 7–13 year follow-ups

Predictor variable	Physical Component Summary (SF-36)					Mental Component Summary (SF-36)
	β	S.E	p	95%CI Lower Bound	95%CI Upper Bound	β	S.E	p	95%CI Lower Bound	95%CI Upper Bound
Intercept	32.21	2.35	.001*	26.83	36.11	47.57	2.32	.001*	42.82	51.94
Time of assessment	− 0.05	0.24	.852	− 0.51	0.46	− 0.08	0.24	.775	− 0.51	0.40
Male sex	− 5.24	2.34	.027*	− 8.64	0.73	− 0.07	0.22	.731	− 5.95	4.80
Younger age at diagnosis	0.25	0.06	.001*	0.13	0.37	0.03	0.07	.544	− 0.10	0.17
Cardiac ejection fraction (EF ≤ 50%)	3.14	2.53	.148	− 1.66	8.19	− 6.85	2.74	.003*	− 11.89	− 0.95
Small fibre neuropathy	11.66	2.29	.001*	6.59	15.51	5.24	3.01	.031*	− 0.74	11.17
Higher GFR (ml/min)	0.21	0.04	.001*	0.12	0.28	0.03	0.04	.326	− 0.06	0.12
History of cerebrovascular events	5.12	1.99	.003*	1.65	9.34	4.51	1.96	.004*	0.70	8.16
− 2LL without interaction	636.9					642.9
Time*Significant predictors
Time*Gender	0.25	0.76	.771	− 1.46	1.62	–	–	–	–	–
Time*Age	− 0.01	0.03	.655	− 0.06	0.05	–	–	–	–	–
Time*Cardiac EF ≤ 50%	–	–	–	–	–	− 0.21	0.80	.796	− 1.45	1.76
Time*Small fibre neuropathy	0.43	0.69	.560	− 1.04	1.64	− 0.05	0.80	.943	− 2.00	1.28
Time*Measured GFR (ml/min)	− 0.01	0.01	.404	− 0.03	0.01	–	–	–	–	–
Time*History of cerebrovascular event	− 0.30	0.76	.713	− 1.78	1.21	0.67	0.63	.916	− 1.47	1.05
− 2LL with interaction	631.7					642.7

* = p < .05

Predictor variables (age, GFR) are centered at mean. Lower scores on the measured GFR indicate worse renal function

Abbreviations: EF, ejection fraction; GFR, Glomerular filtration rate