Fig. 3.

β6-integrin immunohistochemistry of a non-metastatic pancreatic ductal adenocarcinoma (PDAC) localized in the pancreatic tail. Bars indicate 50 µm. The integrin is expressed by most tumor cells (A), and a substantial higher expression is observed in the infiltration margin (B). Invading tumor cells directly adjacent to the surrounding stroma (examples indicated by arrows) regularly show intense upregulation of β6-integrin expression (C). Note that the β6-subunit dimerizes only with the ubiquitous αv (see Fig. 1), which is why β6-IHC is indicative for actual αvβ6 expression