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. 2021 Oct 12;11:106. doi: 10.1186/s13550-021-00842-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — α5-integrin immunohistochemistry of angiosarcoma. A high-grade (A), or a homogeneous (B) or heterogeneous (C) medium-grade expression was observed in 11 out of 12 specimens, and a weak expression in one (D). Note that the α5-subunit dimerizes only with the ubiquitous β1 (see Fig. 1), which is why α5-IHC is indicative for actual α5β1 expression