Table 1. Animal models of SNHL induced by aminoglycoside antibiotics.

Drug	Animal	Route	Dose	Schedule	Duration	Ototoxicity	Reference
Kana + bume	Mouse	s.c. + i.p.	1 mg/g + 0.05 mg/g	Single-dose	1 day	Loss of OHCs and delayed loss of IHCs	(39)
Kana	Guinea pig	s.c.	500 mg/kg	1× daily	7 days	Loss of OHCs, IHCs, and SGNs	(43)
kana	Mouse	s.c.	800 mg/kg	2× daily	15 days	Loss of OHCs. DPOAE thresholds shifted and ABR thresholds increased	(44,45)
Kana + furo	Mouse	s.c. + i.p.	1 g/kg + 300 mg/kg	Single-dose	1 day	Loss of OHCs and IHCs	(46)
Kana + furo	Rat	RWN	200 mg/mL + 50 mg/mL	Single-dose	1 day	ABR thresholds increased at 8–40 kHz	(47)
Kana + furo	Guinea pig	s.c. + RWN	200 mg/kg + 100 mg/kg	Single-dose	1 day	Loss of OHCs, IHCs, and SGNs. CAP thresholds shifted	(48)
Kana + furo	Mouse	i.p.	900 mg/kg + 50 mg/kg	2× daily	15 days	Loss of OHCs and IHCs, and SGNs damaged. ABR thresholds increased to 20 dB at 16 kHz, 35 dB at 22 kHz, and to maximum at 32 kHz	(49)
Gent	Mouse	i.p.	200 mg/kg	3× per week	1 week	ABR threshold increased	(50)
Gent + etha	Chinchilla	i.m. + i.v.	125 mg/kg + 40 mg/kg	Single-dose	1 day	Stereocilia and a cuticular plate of OHC and IHC damaged	(51)
Gent	Guinea pig	i.t.	0.1 mL	Single-dose	1 day	ABR thresholds increased	(52)
Neo	Mongolian gerbil	i.t.	40 mM	Single-dose	1 day	ABR average thresholds increased to 40 dB	(53)
Amik	Rat	i.m.	600 mg/kg	1× daily	15 days	Reduced amplitude of DPOAE	(54)

SNHL, sensorineural hearing loss; kana, kanamycin; amik, amikacin; gent, gentamycin; neo, neomycin; bume, bumetanide; furo, furosemide; etha, ethacrynic acid; i.v., intraveneous; i.m., intramuscular; s.c., subcutaneous; i.p., intraperitoneal; RWN, round window niche; RWM, round window membrane; i.t., intratympanic; OHCs, outer hair cells; IHCs, inner hair cells; SGNs, spiral ganglion neurons; DPOAE, distortion product otoacoustic emission; ABR, auditory brainstem response; CAP, compound action potential.