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. 2021 Sep;9(17):1374. doi: 10.21037/atm-21-2013

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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MiR-552-3p acts as a significant prognosis predictor of GBC. (A) Kaplan-Meier overall survival curve of GBC patients based on miR-552-3p expression; (B) Kaplan-Meier disease-free survival curve of GBC patients based on miR-552-3p expression; (C) miR-552-3p promotes malignant progression of gallbladder carcinoma by reactivating the Akt/β-catenin signaling pathway due to inhibition of the tumor suppressor gene RGMA. GBC, gallbladder cancer; RGMA, repulsive guidance molecule BMP co-receptor a.