Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram of our working hypothesis. Inflammation increases expression level of miR-16 in rat NPCs and also stimulates the exosomes release. The exosomal miR-16 transmitted to normal NPCs sequently induce the cell apoptosis via inhibition of IGF-1 & IGF-1R/PI3K/AKT pathway. MVB, multivesicular bodies; NPCs, nucleus pulposus cells.
