Table 5. Tracers Tested with the Derived Conditions from the Model Reaction^a.

^aReference procedures were reproduced manually and compared to derived conditions. Automated synthesis was carried out and isolated RCY was compared to references. All results created within this work are based on n = 3. Synthetic schemes for precursors can be found in the Schemes S3–S5. Further details on the syntheses can be found in the Figures S20–S49 and Tables S11–S20.

^bEarlier reported syntheses do not use quantitative analysis methods (only HPLC) and do not report isolated RCY and was therefore not suitable for comparison.³⁹

^cMeCN/H₂O, (50:50) was used for elution instead of methanol.

^dtBuOH/MeCN used instead.

^eIn-house data (n = 7). Tracers that were not accessible via standard ¹⁸F-labeling approaches are colored beige.