Table 1. ADME Properties and Molecular Properties for SorA.

parameter	value
molecular weight [g/mol]	520.63
pKa value 0 (in vitro calculation)	10.60
pKa value 1 (in vitro calculation)	11.43
lipophilicity (octanol/water partition coefficient)	1.45
plasma protein binding [%]	86 (mouse), 98.2 (human)
total hepatic clearance (Clint,inc) [μL/min/kg]	921
solubility at pH 7 [ng/mL]	200