Table 3. Constants Used for PBPK/PD Modeling Adapted from Clapham et al. and Ben-Shachar et al.(27−29).

constant	value
kcellclear	4.17 × 10–5 1/h
kcellinfect	3.85 × 10–8 1/h
kcellinfectaugment	4.17 × 10–4 1/h
kclear	6 × 10–3 1/h
kclearaugment	2 × 10–3 1/h
kinfectimmun (only for human PBPK/PD model)	4.16 × 10–8 1/h
kprodvir	4170 1/h
Vir (for mouse PBPK/PD model)	1 × 107 (count)
Vir (for human PBPK/PD model)	5000 (count)