Table 1. Pharmacokinetic Parameters of Naloxone and cNLX-NP Formulations in Rats Following 10 mg/kg i.m. Bolus Doses (n = 3/Group).
| Parameter | cNLX-NP | Naloxone |
|---|---|---|
| t1/2 (h) | 12.67 ± 5.38 | 0.37 ± 0.05 |
| Tmax (h) | 9 (9) | 0.5 (0.5–1) |
| Cmax (ng/mL) | 147 ± 72.5a | 1010 ± 250.85 |
| 1AUC 0-∞ (μg/mL·h) | 3.97 ± 1.69 | 1.25 ± 0.17 |
| 1MRT 0-∞ (h) | 23.51 ± 7.20 | 1.11 ± 0.21 |
| 1Cl/F (mL/kg/min) | 47.17 ± 18.65b | 135.05 ± 17.13 |
| 1observed |
a
p < 0.05..
b
p < 0.01 compared to naloxone. Data are expressed as mean ± SD, except Tmax, which is expressed as median (range).