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. 2021 Sep 17;4(5):1689–1701. doi: 10.1021/acsptsci.1c00184

Figure 5.

Figure 5

Schema indicates the proposed mechanism of ROS quenching and accelerating ligand release of IR700 by l-NaAA. (a) Energy diagram of the photoinduced ligand release reaction of IR700. IR700 receives electrons and becomes a radical anion. l-Cysteine and l-NaAA act as electron donors. The ligand release reaction from the radical anion is accelerated under acidic conditions. Thus, ligand release reaction is accelerated by l-NaAA. (b) Mechanism of l-NaAA for suppressing acute edema after NIR-PIT. During NIR-PIT, ROS is also generated and causes edema. l-NaAA quenches ROS, resulting in preventing acute edema, yet facilitates photoinduced ligand release. ISC, intersystem crossing.