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Alignment of species orthologues of GPR84 predicts those able to be blocked by the 1,2,4-triazines. GPR84 orthologues in human, mouse, rat, pig, dog, and macaque are aligned with residues at position indicator locations 3.34 and 7.46 highlighted. Based on the models of Figure 6, it was predicted that dog, pig, and macaque GPR84 would be antagonized effectively by the 1,2,4-trazine ligands, and direct assessment supported these predictions (Table 2).
