Table 2. Potency of Compound 140 at Species Orthologues of GPR84^a.

compound 140	human	mouse	rat	dog	pig	macaque
IC50 (M)	6.0 × 10–9	>1 × 10–5	8.7 × 10–6	8.1 × 10–9	5.6 × 10–9	6.4 × 10–9

^aIC₅₀ versus EC₈₀ of 6-OAU in cAMP regulation assays performed in CHO cells expressing the identified GPR84 species orthologue.