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. 2021 Jul 19;4(5):1476–1482. doi: 10.1021/acsptsci.1c00134

Figure 1.

Figure 1

Isolation of anticancer lactoferrin fragments. (A) SDS-PAGE of trypsin (T) and pepsin (P) digested lactoferrin. Fragments with positive anticancer activity are indicated with arrows (M, marker; T, Trypsin; P, Pepsin; 1, rtHLF4; 2, rteHLF1; 3, rpHLF2). (B) Anticancer activity of trypsin-digested lactoferrin fragments. (C) Anticancer activity of pepsin-digested lactoferrin fragments. (D) Isolated lactoferrin fragment stability at 37 °C. (E) Purified lactoferrin fragment stability under different pH after 12 h. (F) The sequence length of isolated fragments compared to lactoferrin and other lactoferrin-derived fragments (*P ≤ 0.0083 after Bonferroni correction; each group performed in triplicate).