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. 2021 Oct 12;11(10):e551. doi: 10.1002/ctm2.551

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© 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Schematic of ascites immune cells and their interactions with the tumor. The interactions between ascites immune cells and their potential effect on tumor cells. B220+/CD11b+/CD38+ B lymphocytes (A) and their CD25+/CD119+ regulatory B‐cell subgroup (B) exert antitumor and protumor activity, respectively. The role of CD4+ (C) and CD8+ (D) T cells in exerting cytotoxic activity towards the tumor is linked to the antigen presenting capacity of CD11b+/CD11c+/CD44+ DCs (E). Eosinophils (G) and neutrophils (F) are linked to protumoral and antitumoral properties, respectively. In parallel, monocytes and macrophages (H‐J) exert either a tumor promoting or suppressive effect according to the surrounding microenvironment