Table 2.
Demographic characteristics and performance on One Card Learning accuracy by biomarker group. All participants are cognitively unimpaired. Statistics reported are of the form mean (standard deviation, SD) unless otherwise specified.
| A−T− (n = 211) |
A+T+ (n = 32) |
p-value A−T− vs A+T+ |
Hedge’s g | A+T− (n = 68) |
p-value A−T− vs A+T− |
Hedge’s g | |
|---|---|---|---|---|---|---|---|
| Age, years | 62.83 (9.26) | 75.26 (7.58) | < 0.001 | 71.60 (10.37) | < 0.001 | ||
| Education, years | 15.32 (2.24) | 14.47 (2.59) | 0.051 | 15.10 (2.55) | 0.507 | ||
| Male count (%) | 118 (56%) | 17 (53%) | 0.767 | 36 (53%) | 0.667 | ||
| Follow up duration in years | 2.52 (0.21) | 2.49 (0.25) | 0.434 | 2.50 (0.27) | 0.512 | ||
| Total CBB administrations | 6.08 (1.72) | 5.59 (1.46) | 0.134 | 5.49 (1.80) | 0.016 | ||
| OCL accuracy | |||||||
| sOBJ, z-score | 0.348 (0.746) | 0.024 (0.884) | 0.026 | 0.42 | 0.177 (0.985) | 0.131 | 0.21 |
| ΔOBJ-WSD, z-score | 0.504 (0.766) | 0.338 (0.914) | 0.267 | 0.21 | 0.489 (1.025) | 0.894 | 0.02 |
| ΔOBJ-LR, change per year | 0.021 (0.035) | 0.012 (0.040) | 0.186 | 0.25 | 0.022 (0.046) | 0.803 | −0.03 |
| ΔOBJ-LME, change per year | 0.019 (0.003) | 0.017 (0.004) | < 0.001 | 0.72 | 0.018 (0.004) | 0.03 | 0.30 |
Note. p-values represent linear model ANOVAs for mean comparisons or Pearson’s Chi-squared test for frequency comparisons. A = amyloid; T = tau; OCL= One Card Learning; sOBJ = subtle objective cognitive impairment (cross-sectional). ΔOBJ = subtle objective cognitive decline (longitudinal); WSD = within subjects standard deviation, positive value indicates higher score across repeated assessments (e.g., benefit from practice); LR = Linear regression model; LME = linear mixed effects model.