Table 3.
Comparison of total area under the curve (AUC) with 95% Confidence Intervals (CI) from ROC analyses to distinguish between cognitively unimpaired biomarker groups based on subtle objective cognitive impairment (sOBJ) at baseline and longitudinal decline (∆OBJ) defined using three different methods.
| A−T− and A+T+ comparisons | ||||
|---|---|---|---|---|
|
| ||||
| ΔOBJ Methods (p values) | ||||
| AUC (CI) | WSD | LR | LME | |
| sOBJ | 0.64 (0.53, 0.75) | 0.31 | 0.43 | 0.34 |
| ΔOBJ-WSD | 0.53 (0.42, 0.65) | -- | 0.35 | 0.03 |
| ΔOBJ-LR | 0.56 (0.44, 0.68) | -- | -- | 0.07 |
| ΔOBJ-LME | 0.69 (0.58, 0.80) | -- | -- | -- |
|
| ||||
| A−T− and A+T− comparisons | ||||
|
| ||||
| ΔOBJ Methods (p values) | ||||
| AUC (CI) | WSD | LR | LME | |
| sOBJ | 0.55 (0.47, 0.63) | 0.41 | 0.32 | 0.59 |
| ΔOBJ-WSD | 0.49 (0.41, 0.58) | -- | 0.61 | 0.10 |
| ΔOBJ-LR | 0.48 (0.40, 0.57) | -- | -- | 0.06 |
| ΔOBJ-LME | 0.57 (0.49, 0.66) | -- | -- | -- |
Note. AUC confidence intervals (CI) excluding .50 indicated differentiation of biomarker groups better than chance. Total AUC values were compared across methods [36]. sOBJ = subtle objective cognitive impairment (cross-sectional). ΔOBJ = subtle objective cognitive decline (longitudinal). WSD = within subjects’ standard deviation. LR = annualized change from linear regression model. LME = annualized change from linear mixed effects model.