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. 2021 Sep;9(18):1460. doi: 10.21037/atm-21-4164

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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TRAF6, VCAM1, CD44, and MMP14 were related to PC survival and prognosis. (A) The RNA-seq data of PC and normal tissues were downloaded from the website. The expression distributions of TRAF6, VCAM1, CD44, and MMP14 in PC and normal tissues were analyzed. (B) Prognostic analysis of gene signature in the TCGA set. Kaplan-Meier survival analysis with log-rank test was performed to compare the survival difference between high and low expression groups. (C,D) Hazard ratio and P value of constituents involved in univariate and multivariate Cox regression and some parameters of the TRAF6, VCAM1, CD44, and MMP14 genes. (E) Nomogram to predict the 1-year overall survival of PC patients. ****P<0.0001. TRAF6, tumor necrosis factor receptor-associated factor 6; MMP14, matrix metalloproteinase 14; PC, pancreatic cancer.