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. 2021 Sep;9(18):1454. doi: 10.21037/atm-21-4249

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Sev effectively induced ferroptosis in SH-SY5Y cells. SH-SY5Y cells were exposed to 4.1% sev for different durations (0, 2, 4, 6, or 12 h). (A) CCK-8 assay was performed to detect the viability of SH-SY5Y cells in different groups. (B) SH-SY5Y cells were treated with Fer-1 and DFOM for 12 h and then exposed to 4.1% sev for 6 h, and then subjected to the CCK-8 assay. *, P<0.05; **, P<0.01; ***, P<0.001. Sev, sevoflurane; CCK-8, Cell Counting Kit-8; Fer-1, ferrostatin-1; DFOM, deferoxamine mesylate.