Table 3. Univariate and multivariate analysis of baseline variables affecting DCR.
| Factors | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Gender: M/F | 5.200 | 0.702–38.517 | 0.107 | ||||
| Age (y) | 1.008 | 0.974–1.043 | 0.646 | ||||
| BCLC stage: B/C | 0.561 | 0.245–1.283 | 0.171 | ||||
| Child-Pugh class: B/A | 2.651 | 0.790–8.895 | 0.114 | ||||
| ECOG performance | 0.500 | ||||||
| 0& | |||||||
| 1 | 0.000 | – | 0.979 | ||||
| 2 | 0.617 | 0.277–1.378 | 0.239 | ||||
| Portal vein tumor thrombus: yes/no | 3.336 | 1.374–8.005 | 0.008 | 3.761 | 1.471–9.617 | 0.006 | |
| Extrahepatic metastasis: yes/no | 1.193 | 0.473–3.007 | 0.708 | ||||
| Tumor number: ≥3/<3 | 1.088 | 0.487–2.428 | 0.838 | ||||
| Largest tumor diameter (cm) | 0.969 | 0.881–1.066 | 0.515 | ||||
| α-Fetoprotein level: ≥400/<400 ng/mL | 2.312 | 0.989–5.406 | 0.053 | 1.944 | 0.816–4.631 | 0.134 | |
| ALT (U/L) | 1.006 | 0.995–1.017 | 0.324 | ||||
| AST (U/L) | 0.996 | 0.985–1.007 | 0.440 | ||||
| Albumin (g/L) | 1.032 | 0.957–1.113 | 0.412 | ||||
| Total bilirubin (mmol/L) | 0.972 | 0.921–1.026 | 0.309 | ||||
| PLT (109/L) | 0.998 | 0.994–1.003 | 0.522 | ||||
| PT (s) | 0.815 | 0.573–1.159 | 0.254 | ||||
| ALBI grade | 0.003 | 0.021 | |||||
| 1& | |||||||
| 2 | 2.879 | 1.094–7.580 | 0.032 | 3.420 | 1.261–9.278 | 0.016 | |
| 3 | 7.774 | 2.354–25.679 | 0.001 | 4.637 | 1.357–15.846 | 0.014 | |
| Baseline HBV DNA: ≥2,000/<2,000 IU/mL | 1.678 | 0.666–4.229 | 0.272 | ||||
| HBsAg (IU/mL) | 1.000 | 0.999–1.000 | 0.119 | ||||
| HBeAg: positive/negative | 3.286 | 0.772–13.983 | 0.107 | ||||
| Anti-viral therapy | 0.506 | ||||||
| ETV& | |||||||
| TDF | 0.570 | 0.125–2.603 | 0.468 | ||||
| TAF | 0.739 | 0.300–1.819 | 0.510 | ||||
| Others | 1.813 | 0.499–6.594 | 0.366 | ||||
&, used as the reference category. DCR, disease control rate; BCLC, Barcelona-Clinic Liver Cancer; ECOG, Eastern Cooperative Oncology Group; ALT, alanine aminotransferase; AST, aspartate aminotransferase; PLT, platelet count; PT, prothrombin time; others, LDV or LAM in combination with ADV; ALBI, albumin-bilirubin grade = (log10 bilirubin × 0.66) + (albumin × −0.085); ETV, entecavir; TDF, tenofovir; TAF, tenofovir alafenamide fumarate; LDV, telbivudine; LAM, lamivudine; ADV, adefovir.