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The biogenesis and release of exosomes. First, early endosomes form through endocytosis via the plasma membrane. Second, early exosomes maturate into MVBs via endocytosis. MVBs either fuse with lysosomes for degradation or fuse with plasma membranes. The secreted exosomes contain lncRNAs, circRNAs, and miRNAs, which come from parental cells. MVBs, multivesicular bodies.
