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. 2021 Sep;9(18):1485. doi: 10.21037/atm-21-4198

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Potential clinical applications of exosomes in CLP. (A) Mesenchymal cells and epithelial cells, which participate in palatal fusion, communicate with each other through exosomes, and exosomes are applied as gene transporters to modify aberrant genes; (B) exosomes in the blood of a pregnant woman, amniotic fluid, or placenta are analyzed to diagnose cleft lips and palate; (C) exosomes can be used as drug or gene transporters to treat CLP by binding with a specific target, which increases the accuracy and treatment. CLP, cleft lip with palate.