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. 2021 Sep;9(18):1464. doi: 10.21037/atm-21-4372

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Genome-wide detection and analysis of eccDNA distribution by high-throughput sequencing in matched ESCC samples. (A) The distribution of eccDNAs in the 23 pairs of chromosomes. (B) The eccDNA frequency per Mb in each chromosome. (C) There was no significant relationship between the ratio of coding genes/Mb and eccDNAs/Mb in each chromosome (P=0.27). (D) The distribution of eccDNAs in different classes of genomic regions. (E) The distribution of the counts of eccDNAs generated by different genes. (F,G) The length distribution of eccDNA at ≤5,000 bp. EccDNA, extrachromosomal circular DNA; ESCC, esophageal squamous cell carcinoma; Mb, megabase; bp, base pair.