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. 2021 Sep;9(18):1464. doi: 10.21037/atm-21-4372

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Identification of the differentially expressed eccDNAs between ESCC and matched normal epithelium. (A-C) Cluster, scatter plot, and volcano plot showing the differentially expressed eccDNAs between ESCC and matched normal epithelium. (D,E) The length distribution of the differentially expressed candidate eccDNAs. (F) The distribution of the differentially expressed candidate eccDNA in different classes of genomic regions. EccDNA, extrachromosomal circular DNA; ESCC, esophageal squamous cell carcinoma.