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. 2021 Sep;9(18):1464. doi: 10.21037/atm-21-4372

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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GO and KEGG pathway analysis of the genes associated with the differentially expressed eccDNAs. (A-C) The cellular components, molecular function, and biological processes associated with the down-regulated eccDNAs. (D-F) The cellular components, molecular function, and biological processes associated with the up-regulated eccDNAs. (G) KEGG pathway analysis of the down-regulated eccDNAs in matched ESCC samples. (H) KEGG pathway analysis of the up-regulated eccDNAs in matched ESCC samples. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; eccDNA, extrachromosomal circular DNA; ESCC, esophageal squamous cell carcinoma.