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. 2021 Sep 28;22(6):1374. doi: 10.3892/etm.2021.10809

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Copyright: © Shao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of CD73, APCP and Ado on DRG neurons in hypoxic and hypoglycemic environments. (A) The extracellular Ado concentration in CD73^-/- and CD73 DRG neurons. (B) The Ado concentration in the spinal cord of CD73^-/- and WT mice. (C) The expression of apoptosis-related genes and PKA/CREB signaling pathway genes in CD73- and APCP-treated mouse DRG neurons under oxygen-glucose deprivation. (D) The content of cAMP in CD73- and APCP-treated mouse DRG neurons under oxygen-glucose deprivation. (E) The expression of apoptosis-related genes and PKA/CREB signaling pathway genes in CD73^-/-- and Ado-treated mouse DRG neurons under oxygen-glucose deprivation. (F) The content of cAMP in CD73^-/-- and Ado-treated mouse DRG neurons under oxygen-glucose deprivation. ^*P<0.05, ^**P<0.01 and ^***P<0.001. CD73, ecto-5'-nucleotidase; APCP, α,β-methylene ADP; Ado, adenosine; DRG, dorsal root ganglion; WT, wild-type; PKA/CREB, protein kinase A/cAMP response element-binding protein; NC, negative control.