Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Sequence analysis of HSV-tk1 mutations in FIAUr clones
| Clone | Mutation position | Result |
|---|---|---|
| msh2−/− | ||
| 1 | 151 | Arg to Trp |
| 2 | 430 | +1 frameshift |
| 3 | 430 | −1 frameshift |
| 4 | 430 | −1 frameshift |
| 5 | 430 | −1 frameshift |
| 6 | 430 | −1 frameshift |
| msh2,3−/− | ||
| 1 | 430 | −1 frameshift |
| 2 | ND | Promoter, other |
| 3 | 332 and 734 | Glu to Gly and Thr to Met |
| 4 | 430 | −1 frameshift |
| 5 | 430 | −1 frameshift |
| 6 | 860 | Thr to Met |
The HSV-tk1 sequence was obtained from six FIAUr clones derived from msh2−/− clone 1 and msh2,3−/− clone.
