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. 2021 Oct 12;9:165. doi: 10.1186/s40478-021-01266-8

Fig. 7.

Fig. 7

Tau pathology throughout the brains of mouse lemurs inoculated with AD brain extracts. Representative images of AT8 immunolabelling showing tau pathology following AD brain extract inoculations in mouse lemurs. NFTs were observed at the level of the inoculation sites, e.g. in the posterior cingulate cortex (i) and the parietal area 7 (m), as well as in juxtaposing regions such as the retrosplenial cortex (n, q, s), anterior cingulate cortex (a, c), parietal area 5 (e). They were also detected within the hippocampus (k, o, r) and temporal area 22 (g). Additionally, some regions more distant from the inoculation sites also displayed NFTs, e.g. the temporal area 20 (l, p, t) and the entorhinal cortex (h). Neuropil threads were mainly observed at the inoculation sites, e.g. in the corpus callosum (f, j) and posterior cingulate cortex (i). They were slightly induced around the needle tract (area 7; m), in juxtaposing regions such as the retrosplenial cortex (n), parietal area 5 (e) and in distant regions such as the temporal area 20 (p) and the amygdala (b, d). The red crosses indicate the inoculated region. Scale bars: 500 µm in whole slice images, 20 µm in zoomed images