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. 2021 Oct 12;9:165. doi: 10.1186/s40478-021-01266-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Quantification of NFT pathology following human brain inoculation. Quantification of NFT burden (NFT count per region of interest) in AD- and Ctrl-inoculated lemurs. NFTs were detected in all of AD-inoculated animals and in none of Ctrl-inoculated lemurs. In AD-inoculated animals, NFT burden was increased at the level of the inoculation site, e.g. in the posterior cingulate cortex (a) and the parietal area 7 (b), as well as in juxtaposing regions, including the retrosplenial cortex (c), anterior cingulate cortex (d) and parietal area 5 (e). NFTs were also detected in the hippocampus (f) and in some regions more distant from the inoculation sites, including the temporal area 20 (g), frontal area 4 (h) and entorhinal cortex (i). No statistical difference was reported between AD1- and AD2-inoculated lemurs (p > 0.05; Mann–Whitney’s test). Data are shown as mean ± s.e.m