Table 3.
MR Steiger directionality test and colocalization for four top findings in ER+ breast cancer.
| CpG | PP.H0 | PP.H1 | PP.H2 | PP.H3 | PP.H4 | Steiger p-value | Evidence |
|---|---|---|---|---|---|---|---|
| ER+ breast cancer | |||||||
| cg2583948 | 4.38E-27 | 4.19E-02 | 1.00E-28 | 0 | 9.58E-01 | 1.01E-34 | Strong |
| cg07602659 | 3.43E-07 | 8.83E-01 | 8.13E-11 | 9.29E-05 | 1.17E-01 | 1.86E-21 | Weak |
| cg04209460 | 5.52E-43 | 2.12E-01 | 2.05E-45 | 0 | 7.88E-01 | 1.92E-57 | Moderate |
| cg20375836 | 5.82E-06 | 3.67E-01 | 1.01E-08 | 0 | 6.33E-01 | 1.83E-11 | Weak |
ER indicates estrogen receptor; PP, posterior probability.