Table 3.
Overview over quantities related to the effect of hypoxia in the primary CTV and hypoxic volume for each patient
| Patient | Dose to PTV [GyRBE] | Volume of GTVhypoxic [cc] | DE | LETd in CTVprim [keV/µm] | pO2 in GTVhypoxic [mmHg] | pO2 in CTVprim – GTVhypoxic [mmHg] | OER in GTVhypoxic | OER in CTVprim-GTVhypoxic |
|---|---|---|---|---|---|---|---|---|
| 1 | 60 | 48.3 | 1.17 | 2.2 (2.0,2.4) | 5.4 (4.5,6.6) | 29.5 (12.9,30) | 1.22 (1.18,1.27) | 1.0 (1.0,1.08) |
| 2 | 70 | 58.9 | 1.15 | 2.3 (2.2,2.6) | 6.0 (5.3,6.9) | 25.1 (11.9,30) | 1.2 (1.17,1.23) | 1.0 (1.0,1.08) |
| 3 | 70 | 19.8 | 1.10 | 1.9 (1.6,2.3) | 7.9 (7.0,8.7) | 30.0 (23.3,30) | 1.15 (1.13,1.17) | 1.0 (1.0,1.02) |
| 4 | 70 | 37.5 | 1.13 | 2.1 (1.9,2.4) | 6.6 (6.0,7.2) | 30.0 (15.7,30) | 1.18 (1.16,1.2) | 1.0 (1.0,1.05) |
| 5 | 70 | 8.0 | 1.12 | 2.6 (2.4,2.9) | 7.2 (6.1,8.4) | 30.0 (19.0,30) | 1.16 (1.13,1.2) | 1.0 (1.0,1.03) |
| 6 | 70 | 52 | 1.22 | 2.5 (2.0,3.0) | 5.0 (3.5,6.4) | 29.2 (14.3,30) | 1.24 (1.19,1.34) | 1.0 (1.0,1.06) |
| 7 | 70 | 46.8 | 1.10 | 1.9 (1.7,2.1) | 8.2 (6.8,9.3) | 30.0 (30,30) | 1.14 (1.12,1.17) | 1.0 (1.0,1.0) |
| 8 | 60 | 23.3 | 1.07 | 2.2 (2.0,2.4) | 9.2 (8.3,10.5) | 30.0 (30,30) | 1.12 (1.1,1.14) | 1.0 (1.0,1.0) |
| 9 | 70 | 20.9 | 1.13 | 2.2 (1.9,2.6) | 6.7 (6.2,7.2) | 28.0 (12.7,30) | 1.18 (1.16,1.19) | 1.0 (1.0,1.07) |
| 10 | 70 | 5.2 | 1.12 | 2.6 (2.2,3.2) | 7.4 (6.3,8.4) | 30.0 (19.9,30) | 1.16 (1.13,1.19) | 1.0 (1.0,1.03) |
| Cohort Median | 70 | 30.4 | 1.13 | 2.2 | 7 | 30 | 1.17 | 1 |
For LETd, pO2 and OER values, the median is reported with the 25 and 75 percentiles indicated in brackets. While the normoxic part of the CTV resulted in an OER of 1, the decreased levels of oxygen within the GTVhypoxic led to increased OER, thus higher amounts of dose necessary to control the tumour