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. 2021 Sep 3;23:124–137. doi: 10.1016/j.omto.2021.08.016

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© 2021.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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The expression level of long non-coding RNA RP11-147L13.8 was downregulated in tumor tissue and chemo-resistant cell lines in gallbladder cancer

(A) The heatmap presented the expression level of the expression profiles of lncRNAs and mRNAs between 4 pairs of GBC tissue and normal tissue. (B) The differentially expressed genes (DEGs) enriched biological process includes transmembrane transport, cell-cell signaling, Jun-MAPK signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, and cation transport. (C) The DEGs between GBC-SD and drug-resistant GBC-SD cells are shown. (D) 1,223 genes were differently expressed between GBC tumor tissues and normal tissues, although 1,303 genes were differentially expressed between normal GBC cell lines and drug-resistant GBC cell lines. Besides, 211 overlap genes were found between two gene sets. (E) The top 20 different expressed lncRNAs between GBC-SD and drug-resistant GBC-SD cell lines are shown. (F) The expression level of RP11-147L13.8 was significantly downregulated in drug-resistant tumor tissues and drug-resistant GBC-SD cell lines.