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. 2021 Oct 12;19:314. doi: 10.1186/s12951-021-01056-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Physicochemical characterization of nanocarriers. A N₂ adsorption/desorption isotherms and B pore size distribution of SPION@MSNs and Au-NPs@DOX. C VSM curves of SPION@MSNs and PEG-Au-NPs@DOX. D The conjugation of EpCAM aptamer was verified by electrophoresis. E TGA analysis curves of (a) SPION@MSNs, (b) SPION@MSNs-NH₂, (c) Au-NPs@DOX, (d) PEG-Au-NPs@DOX and (e) Apt-PEG-Au-NPs@DOX. F In vitro DOX release profile of Au-NPs@DOX at pH 7.4 and pH 5.4 (data presented as mean ± SD, n = 3). SPION Superparamagnetic iron oxide nanoparticle, MSN Mesoporous silica nanoparticle, NP nanoparticle, DOX Doxorubicin, VSM Vibration sample magnetometer, PEG Polyethylene glycol, Apt Aptamer, EpCAM Epithelial cell adhesion molecule, TGA Thermal gravimetric analysis