Table 3.

IC₅₀ values of free DOX and nanocarriers on HT-29 and CHO cells during 24, 48, and 72 h of treatments

Treatments	IC50 (µg/ml) ± SD (HT-29 cells)			IC50 (µg/ml) ± SD (CHO cells)
	24 h	48 h	72 h	24 h	48 h	72 h
Free DOX	8.86 ± 1.78	6.83 ± 1.06	4.89 ± 1.06	14.00 ± 1.07	9.63 ± 1.08	5.66 ± 1.06
PEG-Au-NPs@DOX	33.90 ± 1.07	25.38 ± 1.07	15.99 ± 1.05	102.2 ± 1.12	77.01 ± 1.10	54.94 ± 1.26
Apt-PEG-Au-NPs@DOX	9.72 ± 1.08	7.29 ± 1.09	5.52 ± 1.09	320.5 ± 1.24	243.2 ± 1.27	179.2 ± 1.29

SPION Superparamagnetic iron oxide nanoparticle, MSN Mesoporous silica nanoparticle, DOX Doxorubicin, PEG Polyethylene glycol, Apt Aptamer