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. 2021 Sep 18;13(18):22286–22297. doi: 10.18632/aging.203534

Figure 1.

Figure 1

Gain of function of ASXL1 was common in adrenocortical carcinoma (ACC). (A) Reproduced from TCGA pan-cancer cohorts (Firehose) and ACC cohort (N = 75), shown were Gain and amplification of ASXL1 across cancer types; (B) Cases with gain of function of ASXL1 (N = 51), ASXL2 (N = 17) and ASXL3 (N = 3) and box plot of expressions of ASXL1, ASXL2 and ASXL3 against copy number alteration; (C) Kaplan-Meier plots of overall and disease-free survival in ACC patients with or without ASXL1 overexpression, compared by the log-rank test; (D) Volcano plot of significantly enriched mutation and expression of genes in ACC cases with gain of function of ASXL1; (E) Bar figure showing frequency of gene mutation in ASXL1-altered (gain of function) and -unaltered group; (F) Functional annotation by NET-GE of genes enriched in (D) using KEGG; (G) GSEA analysis of genes enriched in (D) (ns = not significant; q value denoting false discovery rate, *P < 0.05; **P <0.01).