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. 2021 Sep 22;13(18):22298–22314. doi: 10.18632/aging.203538

Table 2. Results of univariate and multivariate analyses of postoperative patients’ survival by Cox’s proportional hazard model.

Varieties n Univariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p value
Age (≤60 or > 60 years) 44/73 0.796 0.503–1.259 0.330
Gender (Male/Female) 90/27 0.902 0.540–1.507 0.694
Size of tumor (≤5 or > 5 cm) 79/38 0.356 0.226–0.560 <0.001* 0.795 0.464–1.361 0.402
Depth of tumor invasion (T1–2/T3–4) 31/86 0.241 0.137–0.421 <0.001* 0.429 0.211–0.873 0.020
Lymph node metastasis (negative/positive) 49/68 0.271 0.168–0.437 <0.001* 0.498 0.233–1.064 0.072
Degree of differentiation (moderate-well/poor) 59/58 0.576 0.374–0.887 0.012* 0.81 0.503–1.304 0.385
Venous invasion (negative/positive) 78/39 0.384 0.247–0.597 <0.001* 0.725 0.429–1.226 0.231
Neural invasion (negative/positive) 78/39 0.466 0.297–0.729 0.001* 1.182 0.691–2.023 0.541
TNM staging (I–II/III–IV) 62/55 0.243 0.153–0.385 <0.001* 0.832 0.394–1.759 0.631
AKR1B10 expression (negative/positive) 70/47 2.401 1.504–3.832 <0.001* 1.161 0.673–2.004 0.591

*P < 0.05.