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The pedigrees of families with pathogenic germline mutations carriers (A-D) and germline variant of uncertain significance carrier (E). In all pedigrees, probands are indicated by arrows. The type of cancer and the age at disease diagnosis are described under the filled black square/circle. AML - acute myeloid leukemia, CLL - chronic lymphocytic leukemia, Pr - prostate cancer, Ut - uterine cancer, St - stomach cancer, Br -breast cancer, Bn - brain cancer, n.d. - no data
