Figure 6.

Metabolic glycoengineering approach for membrane modification. (A) Scheme of glycoengineered T cell membrane extraction and N₃-labeled membrane-coated nanoparticles (N₃-TINPs) construction. (B) Illustration of tumor-bearing mice with BCN group expression upon Ac₄ManN-BCN injection. N₃-TINPs could targeted anchor in tumor region through immune recognition of T cell membrane and bioorthogonal reaction between BCN and N₃ groups, and effectively eliminate tumors based on ICG-mediated photothermal effects. (C) Identification of N₃ group on the surface of N₃-TINPs. Tumor cells were incubated with N₃-TINPs or TINPs (control) for 1 h, and then stain with anti-CD3-FITC and DBCO-Sata650. (D) In vivo photothermal therapy efficacy based on tumor growth curves of different groups in Raji tumor-bearing mice (n = 5). Reproduced with permission from ref 90. Copyright 2019 John Wiley & Sons.