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. 2021 Sep 28;9:717601. doi: 10.3389/fcell.2021.717601

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Copyright © 2021 Zhang, Guo, Su, Luo, Tan, Xu, Ye, Tong, Liu, Li, Chen and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment analysis and association of transcriptome traits and TIME phenotypes in the Chinese Glioma Genome Atlas (CGGA) cohort. (A) Gene set variation analysis (GSVA) revealed P53 and IL2-STAT3 signaling pathways were enriched in TIME cluster C; and TNFA via NFκB signaling pathway and downregulation of kirsten rat sarcoma viral oncogen (KRAS) were enriched in TIME cluster A. Color represents pathway enrich scores: color blue refers to high score and yellow low. (B) TIME patterns were discriminated by distinct expression levels of signatures related to epithelial–mesenchymal transition (EMT), immune checkpoint, and immune activation by the Kruskal–Wallis test. ns, p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001; and ****p < 0.0001.