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. 2021 Sep 28;9:717601. doi: 10.3389/fcell.2021.717601

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Copyright © 2021 Zhang, Guo, Su, Luo, Tan, Xu, Ye, Tong, Liu, Li, Chen and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of TIMEscore and glioma clinicopathologic features. (A–F) Barplot of TIMEscore in groups with different clinicopathologic characteristics in CGGA set, compared with the Wilcoxon test. (G–I) K-M curves for patients with glioma in the CGGA cohort stratified by 1p19q codeletion status (G), isocitrate dehydrogenase (IDH) mutation status (H), O⁶-methylguanine-DNA methyltransferase (MGMT) methylation status (I), and TIMEscore. *p < 0.05; **p < 0.01; ***p < 0.001; and ****p < 0.0001.