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. 2021 Sep 28;9:717601. doi: 10.3389/fcell.2021.717601

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Copyright © 2021 Zhang, Guo, Su, Luo, Tan, Xu, Ye, Tong, Liu, Li, Chen and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between the TIMEscore and somatic variants. (A) Tumor mutation burden (TMB) differences in the high and low TIMEscore subgroups. Wilcoxon test, p < 0.0001. (B) K-M curves for high and low TMB groups of TCGA glioma cohort. (C) K-M curves for patients in TCGA glioma cohort stratified by both TMB and TIMEscore. (D,E) The oncoPrint was constructed using low TIMEscore on the left (D) and high TIMEscore on the right (E). The columns represent samples. *p < 0.05; **p < 0.01; ***p < 0.001; and ****p < 0.0001.