TABLE 1.

Cox regression analysis of the clinical variables, and survival in the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) cohorts.

Covariate	CGGA_OS cohort			TCGA_OS cohort			TCGA_PFS cohort
	HR	95% CI	P	HR	95% CI	p	HR	95% CI	p
Univariate Cox regression analysis
TIMEscore	2.718	2.450–3.016	<0.001	2.184	1.877–2.543	<0.001	1.839	1.629–2.077	<0.001
Gender	1.036	0.878–1.223	0.675	1.092	0.824–1.447	0.541	1.045	0.837–1.305	0.697
Age	1.028	1.021–1.036	<0.001	1.074	1.062–1.086	<0.001	1.040	1.032–1.048	<0.001
Grade	4.115	3.467–4.885	<0.001	10.88	7.783–15.221	<0.001	5.598	4.392–7.135	<0.001
IDH status	3.039	2.560–3.608	<0.001	8.84	6.561–11.91	<0.001	6.826	5.351–8.707	<0.001
1p19q status	4.368	3.312–5.759	<0.001	3.82	2.449–5.957	<0.001	3.333	2.397–4.634	<0.001
MGMTp status	1.202	1.009–1.432	0.039	3.223	2.419–4.294	<0.001	2.856	2.241–3.639	<0.001
Multivariate Cox regression analysis
TIMEscore	2.042	1.734–2.405	<0.001	1.847	1.435–2.377	<0.001	1.434	1.159–1.774	0.001
Age	1.009	1.002–1.016	0.016	1.053	1.039–1.067	<0.001	1.014	1.004–1.025	0.006
Grade	2.000	1.597–2.503	<0.001	5.020	3.065–8.223	<0.001	2.799	1.796–4.361	<0.001
IDH status	0.796	0.622–1.017	0.068	1.240	0.695–2.214	0.467	2.074	1.263–3.407	0.004
1p19q status	1.959	1.426–2.693	<0.001	1.628	0.959–2.765	0.071	1.440	0.959–2.163	0.079
MGMTp status	1.071	0.888–1.292	0.475	1.275	0.905–1.798	0.165	1.212	0.901–1.628	0.203

HR, hazard ratio; CI, confidence interval; CGGA, Chinese Glioma Genome Atlas; TCGA, The Cancer Genome Atlas; IDH, isocitrate dehydrogenase; MGMTp, O⁶-methylguanine-DNA methyltransferase promoter.