Table 1.
Major growth-associated FAK and/or Src signaling pathways in the top 5 deadliest cancers according to the American Cancer Society.
| Cancer Type | Species | Elevated Kinase Activity | Growth-Associated Signaling Pathways | References (PMID) |
|
|---|---|---|---|---|---|
| FAK | Src | ||||
| Lung | Human | + | + | PI3K/Akt | [93,94] |
| Human | + | MEK/MAPK | [94,95] | ||
| Human | + | YAP/Hippo | [96,97,98,99] | ||
| Colorectal | Human | + | + | PI3K/Akt | [100] |
| Human | + | EGFR | [101,102] | ||
| Human, rat |
+ | EGFR/ERK | [103] | ||
| Human | + | ERK | [104] | ||
| Breast | Human | + | STAT3 | [105] | |
| Human | + | + | HER receptors/PI3k/Akt /MAPK |
[106,107] | |
| Human | + | YAP/Hippo | [108,109] | ||
| Pancreatic | Human | + | + | Ras/Raf, PI3K/Akt | [81,83,110] |
| Human, mouse |
+ | + | ERK | [108] | |
| Human | + | EGFR/Erb2, ERK, STATs, TGF-β | [111,112,113] | ||
| Human, mouse |
+ | EGFR/STAT3 | [114] | ||
| Prostate | Human, mouse |
+ | SFK (Src family kinases) Lyn | [80] | |
| Human | + | PI3K/Akt | [115] | ||
| Human | + | EGFR/Akt/ERK | [116,117,118] | ||
| Mouse | + | MAPK | [119] | ||