Table 2.

Nine DEmiRs identified in the comparison between TT and NNT by microarray analysis (n = 11) and chosen for validation in the independent cohort of PeC patients (n = 13) by qRT-PCR.

Regulation	DEmiR	Microarray		qRT-PCR
		FC	FDR	FC	SD	FDR
Downregulated	miR-432-5p	0.07	0.0048 *	0.41	0.51	0.004 *
	miR-487b-3p	0.12	0.0079 *	0.44	0.45	0.004 *
	miR-145-5p	0.18	0.0088 *	0.33	0.37	0.005 *
	miR-30a-5p	0.21	0.0067 *	0.57	0.32	0.002 *
	miR-149-5p	0.29	0.0308 *	0.79	1.04	0.097
Upregulated	miR-200a-5p	2.93	0.0048 *	3.48	1.28	0.004 *
	miR-224-5p	6.59	0.0083 *	5.70	3.19	0.001 *
	miR-31-3p	12.38	0.0002 *	41.62	41.43	0.004 *
	miR-31-5p	38.32	0.0048 *	122.28	127.75	0.001 *

DEmiR: differentially expressed miRNA; TT: tumor tissue; NNT: non-neoplastic tissue; n: number of individuals; PeC: penile cancer; FC: fold change; SD: standard deviation; FDR: false discovery rate; qRT-PCR: quantitative Reverse Transcription Polymerase Chain Reaction; * p < 0.05.